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Guide To Nootropics For Depression

The once-enjoyed activity now turned into sadness, hopelessness, and a lack of interest in activities is Depression. Using Nootropics for Depression is a most discussed topic.

In this article, we are going to learn Signs of Mental Health, Neurotransmitters, and the Best Nootropics for you, in terms of both synthetic and natural ways.

Signs of Mental Health

  • Feeling sad or down
  • Inability to concentrate
  • Excessive fears or worries
  • Extreme feelings of guilt
  • Low energy
  • Paranoia or Hallucinations
  • Inability to cope with daily problems
  • Sudden changes in personality and behavior
  • Major changes in eating habits
  • Inability to be productive at work/studies
  • The dramatic change in sleeping patterns
  • Communication problems
  • Sexual problems
  • Excessive anger
  • Hostility, or violence
  • Suicidal thoughts
Signs of Mental Health


Neurotransmitters are chemical messengers that transfer signals in the nervous system. They transform information from one neuron to another and regulate mood, sensation, movement, and thought.

Different levels of Neurotransmitters.

There are four levels of Neurotransmitters. They are

  • Dopamine
  • Serotonin
  • Acetylcholine
  • Gaba.



Dopamine and Serotonin are chemical messengers that control body functions. Both act similarly but operate differently. Both cant cause depression on their own but researchers believes deficiency and imbalance of Dopamine and Serotonin is a major factor. Researchers.

It is a system that controls motivations, desires, and carvings. They keep you excited and make you do things and motivate you.

  • Mood
  • Sleep
  • Learning
  • Movement
  • Alertness
  • Blood Flow
  • Urine Output


Serotonin is a group of chemical agents that release by neurons present in the brain.

It controls

  • Sleeping Pattern
  • Mood and Emotions
  • Appetite and Digestion
  • Concentration and Understanding
  • Hormonal Activity
  • Body Temperature
  • Blood Clotting


Acetylcholine is a chemical messenger in the nervous system that helps transmit signals between nerve cells. They increase processing speed and keep you focused Gaba tones down. It plays an important role in functions such as

  • Muscle Movement,
  • Heart Rate Regulation
  • Learning
  • Memory


GABA (Gamma-Aminobutyric Acid) is a neurotransmitter. it slows down or blocks nerve impulses in the nervous system. It helps regulate brain activity and balance the nervousness of nerve cells. It promotes

  • Calmness
  • Reduces Anxiety.

What causes Depression

Dopamine, Serotonin, Acetylcholine, and Gaba interact with each other to maintain a careful chemical balance within the body. Any abnormal levels of these can lead to several different medical conditions.

Imbalances in these neurotransmitters play a role in the development of depression and other mood disorders. Neurotransmitters can also result in distinct conditions that affect different bodily functions.

What are the properties of Nootropics?

The best Nootropics are supplements that claim to enhance cognitive functions such as Memory, motivation, creativity, and Attention. The properties of each nootropic vary depending on the type of substance. Here are some common properties.

  1. Nervous System Protection: Few nootropics protect the brain from damage and disease.
  2. Improved Blood Flow: Nootropics increase blood flow to the brain, providing it with more oxygen and nutrients.
  3. Increased Brain Nerve Cell Communication: Some nootropics improve communication between neurons (brain nerve cells) in the brain, leading to improved understanding function.
  4. Enhanced Reorganization of Brain: Some nootropics increase the brain’s ability to change and adapt, which helps in improved learning and memory.
  5. Increased Dopamine and Serotonin: Some nootropics such as dopamine and Serotonin increases the levels of neurotransmitters, involved in learning, memory, and attention.

Take note that there is no scientific evidence to prove that the above properties are 100% genuine, although little research on Nootropics found that they have positive results on brain.

Same way not all nootropics are cleared for side effects, some carry side effects or interact with other medications.

Also, Read this Thesis Nootropics: Quality, Ingredients, and Uses.

Best Nootropics for Depression. (Synthetic)

Synthetic Artificial Nootropic
  • Noopept  
  • Piracetam
  • Citicoline
  • Phosphatidylserine (PS)
  • Kratom Aniracetam


Noopept is one of the best nootropics for depression that works by boosting levels in the brain of BDNF (brain-derived neurotrophic factor).

BDNF is a protein that was actually only first set apart in 1989. It’s active in the region of brain memory and brain cortex, the areas that are vital to learning, memory, and higher thinking. It promotes clear thinking and staying positive.

So what you’re getting with a dose of Noopept are the following benefits:

  • Boost levels of Alpha Brain Waves
  • Stimulates clear thinking and removes confusion
  • Faster and better thinking
  • Has the comfort of a Sedative
  • Clearer thinking
  • Higher amount of positivity


A smart drug that the Soviet Union didn’t actually produce it wanted for. Although there was a finding that Piracetam has cognitive-enhancing benefits.

Mainly, it’s a GABA synthetic generated. It acts as a central nervous system depressant, makes you calm down, but keeps you focused.

The benefits of a dose of piracetam are :

  • Better Communication and Performance
  • Memory Improvement and recall
  • Enhanced higher learning abilities
  • Higher confidence and focus
  • Cut down Anxiety and Depression

Piracetam is primarily useful and the best nootropic for depression. It helps to improve memory and learning abilities. It has neuroprotective properties, as it protects the brain from damage or injury.

Such properties are beneficial for individuals with depression, or those having damage to certain regions of the brain.

Piracetam also improves the functioning of chemical agents released by neurons (nerve cells), which could help to lower the symptoms of depression.


Citicoline suggest as a potential treatment and the best nootropics depression for depression.

  1. Chemical messenger support: Citicoline increases the levels of certain nerve systems in the brain, like dopamine and acetylcholine, which regulate mood and emotional states.
  2. Improved Brain Function: Citicoline supports healthy brain function, which helps to decrease depression symptoms.
  3. Antioxidant Properties: Citicoline is an antioxidant. It helps to protect the brain from oxidative stress and cellular damage. Depression increased oxidative stress and cellular damage in the brain.
  4. Stimulation of new Neurons: Some studies indicate that citicoline helps stimulate the growth of new neurons in the brain, which could have a positive impact on depression symptoms.

Phosphatidylserine (PS)

To treat depression Phosphatidylserine (PS) a nutrient is useful, and here are some of the reasons

  1. Balance of Mood: PS maintains the levels of a certain chemical messenger, including serotonin and dopamine, for mood regulation. By improving neurotransmitter function, PS has an impact on depression symptoms.
  2. Improved Reasoning Function: PS supports healthy reasoning function, which has a positive impact on depression symptoms. This function is of great value as depression often leads to symptoms such as difficulty concentrating or memory problems.
  3. Reduced Stress: PS reduces stress and improves mood. Depression increases levels of stress.
  4. Anti-inflammatory Effects: PS has an anti-inflammatory effect. It helps reduce inflammation in the brain and improves depression symptoms. Depression increases inflammation in the brain.


Kratom impacts reducing depression, and mood swings, and improving energy levels.

  1. Mood Management: Kratom controls the levels of certain neurotransmitters, like dopamine and serotonin, and regulates mood.
  2. Pain Relief: Kratom acts as a pain reliever, and depression is often accompanied by physical symptoms such as pain, one way to improve is with kratom use.
  3. Boosts Energy and Focus: It is easy to increase energy and focus after using kratom. So Kratom has a positive impact on depression symptoms.


Controls Mood: Aniracetam controls certain levels of neurotransmitters. Examples are acetylcholine and glutamate, which regulate mood.

Improved Awareness Function: Aniracetam shows to support healthy awareness function, which has a positive impact on depression symptoms. Depression is often accompanied by awareness symptoms such as difficulty concentrating or memory problems.

Antidepressant Effects: Some studies show that Aniracetam has the potential as an antidepressant. However, more research requires to understand its effects.

Best Nootropics for Depression. (Natural)

  • Bacopa Monnieri: This herbal supplement has been useful in Ayurvedic medicine for centuries and has shown the potential to improve mood and reduce symptoms of depression in limited studies.
  • Rhodiola Rosea: This herb has been useful in traditional medicine to improve mood and reduce stress. Some studies have shown that it may also improve symptoms of depression.
  • S-Adenosylmethionine (SAMe): SAMe is a naturally occurring molecule that involves the production of neurotransmitters that shows the potential to improve mood and reduce symptoms of depression in some studies.
  • L-Theanine: This amino acid is found in green tea. It shows to improve mood, reduce anxiety, and improve sleep quality in some studies.
  • Ginseng: Ginseng is one of the oldest and most popular adaptogenic herbs. Stemming from traditional Chinese medicine, it’s a long, light brown root with green leaves and a bitter flavor have a positive effect on the immune system
  • Lion’s Mane Mushroom: Lion’s mane mushroom is a shaggy white mushroom. It needs to be consumed cooked, raw, dried, or in tea form for improved brain function.

You may also like Nefiracetam in the Therapy of Alzheimer’s Disease


Nootropics are typically known as an alternative treatment for Depression. However, a lot of thoughts and processes are going around on how Nootropics work and how to best use them. We hope that this article helped you find the best treatment option.

Hope we provided you with information on the range of Nootropics that exist and the differences between synthetic and natural ones.

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