What is Pramiracetam? Properties, Benefits, and Effects.

Pramiracetam is a newer nootropic in the racetam family. The drug advertises as a “brain booster” or cognitive enhancer. People take it to try and improve their memory, focus, and mental performance.

Although in the lab, it shows not to influence directly by different levels of Neurotransmitters like Norepinephrine, Serotonin, Dopamine, and Gaba in the brain.

It shows to increase nitric oxide activity in the brain, which helps Cerebral circulation and provides the productivity of brain cells to function properly.

Findings

Several animal and human studies show that Pramiracetam has a significant effect on memory in one trial test. Scientists found that the rats had great improvement in control and the effect lasted for 24 hours.

This is a significant study as pramiracetam doesn’t require multiple doses or a couple of weeks to build up your system. It works from the first day you use it.

Pramiracetam may also modulate the levels of other neurotransmitters, such as dopamine and serotonin, which play a role in mood, motivation, and attention.

In order to increase its potency and bioavailability the structure of pramiracetam is chemically modified from that of piracetam.

In the U.S., the drug is available to the nootropic community.

Properties of Pramiracetam

Research has shown Pramiracetam to be up to 30 times more potent than the original Piracetam. It boosts acetylcholine synthesis and use in the brain and increases cerebral circulation.

As a nootropic, it smoothly penetrates the blood-brain barrier. Pramiracetam is fat-soluble and consumed with a healthy fat intake.

Nootropic dosage increases the amount and efficiency of acetylcholine by influencing the high-affinity choline optic system in your brain. This increase has a huge effect on insight and memory.

It improves logic and understanding of complex mathematical and technical subjects. One may also find it easier to recall long-forgotten memories through improved cerebral circulation.

The Effects of Pramiracetam

Helps with Memory and Recall
Improves Mental Performance and Focus
Increases Blood Flow to the Brain
Low Toxicity Compared to Other Similar Drugs.

Benefits

Improved Memory and Recall Ability
Increased Learning Capacity and Focus
Enhanced Sensory Perception
Boosted Mental Energy and Alertness
Reduced Social Anxiety and Stress Levels
Increased Mental Endurance
Enhanced Problem-solving Skills
Improved Mood and Motivation
Increased Cerebral Blood Flow
Potential Neuroprotective Effects.

Side-Effects of Pramiracetam

Pramiracetam is a nootropic drug, useful to enhance cognitive function. It is generally safe, but like all drugs, it can have side effects.

According to one preliminary study in both animals and humans, a nootropic is relatively safe and “well-tolerated,” causing few major side effects [16].

Similarly, a trial carried out on 12 healthy volunteers showed no adverse side effects at any dosage (from 400 to 1,600mg) [18].

However, this investigation tested a one-time dose of pramiracetam. So no correct conclusions are there to study and side- effects of nootropics.

Pramiracetam Dose

On account of earlier studies and information about the dosages used, Pramiracetam Dose is useful so far. The information below is not intended as a guide for personal use, as adequate data about its potency, safety, or overall effects in healthy human populations are not currently available.

It is generally available in the form of powder, tablets, or pre-made capsules. There are reports claiming that the powder form of the nootropic dose has a strong unpleasant taste. So capsule or tablet forms are preferred.

At present, the confirmation on using nootropics in humans uses either 400mg thrice daily or 600mg twice daily. Note that both of these doses combine to make a total of 1,200mg of pramiracetam daily. [19].

In Europe, this nootropic treats dyslexia, ADHD, dementia, and other memory problems. Brand names for prescription pramiracetam include Pramistar, Neupramir, and Remen.

Pramiracetam vs Phenylpiracetam

Both are nootropics, or drugs useful to enhance cognitive function. They are both derivatives of piracetam, although there are some differences between the two.

Pramiracetam is more potent than piracetam, with a longer half-life and a higher level of bioavailability. It improves memory, focus, and learning ability, and is commonly useful to treat cognitive impairment and memory loss.

Phenylpiracetam, on the other hand, is a modified version of piracetam that includes a phenyl group.

Phenylpiracetam improves memory, focus, and attention, as well as physical performance and energy levels.

If you’re considering taking a nootropic drug, it’s important to consult with a qualified healthcare provider to determine if it’s safe and appropriate for you, and to discuss any potential risks or side effects.

Buy, Dosage, and Recommendations

Where to Buy Pramiracetam?

The nootropic is available from many vendors; if you simply do a Google search. There are many vendors available for you right now.

As for its dose, It is available in tablet, capsule, and powder form. Tablets and capsules are usually 250 or 300 mg each.

In Europe, Pramiracetam is a prescription drug under the brand names Pramistar, Neupramir, or Remen.

How long Does the Pramiracetam Effect Show?

The effect reaches its peak about 30 minutes after consumption and has an average half-life of 5 hours.

When to Take Pramiracetam?

The best time to take would be once after breakfast and another dose after lunch, keeping a gap of 5-hour time intervals.

How to Take Pramiracetam?

It is advised to take the dose after food, it can still be taken after food depending on personal preference.

How Long Does the Pramiracetam Effect Last?

The effect lasts about 4 to 6 hours.

Why is Pramiracetam so Expensive?

There are a lot of talks regarding the dose being expensive, the supplement from Nootropics Tipo is $9.99 for 5g and $26.99 for 15g.

How much Choline to take with Pramiracetam?

It is recommended 300 milligrams of Alpha GPC with each Pramiracetam dose. If you prefer Citicoline as a choline source then the recommended source would be 250 milligrams.

Disclaimer: This post is not a recommendation or endorsement for the use of Pramiracetam. The FDA has not approved this drug for any specific medical or other use, and the available research on it is still in a very early stage, without adequate data to come to any real conclusions about its general effectiveness or human safety. This post is written for informational purposes only, and our goal is solely to inform people about what science currently says about its mechanisms, potential effects, and possible side effects

You may also like Guide To Nootropics For Depression.

FAQ

What does Pramiracetam do to the Brain?

The nootropic drug is believed to enhance cognitive function by increasing blood flow to the brain and increasing the activity of certain neurotransmitters.

It is thought to improve memory, focus, and learning ability. The nootropic drug has been shown to significantly increase high-affinity choline uptake (HACU) in the hippocampus.

This action boosts acetylcholine (ACh) use which accounts at least in part for Pramiracetam’s ability to enhance cognition and memory.

What is the Source of Pramiracetam?

Pramiracetam is a synthetic nootropic drug, meaning it is not found in nature and is produced in a laboratory setting.

It was first developed by Parke Davis in the 1970s. and is now manufactured and sold by various pharmaceutical companies. Pramiracetam is legal and sold in different parts of the world as a prescription drug.

Parke Davis was one of the largest and oldest drug makers.
Pramiracetam is derived from piracetam, which is a natural compound found in some plants.

How does Pramiracetam Feel?

There are many reports saying taking pramiracetam makes your brain fire quickly on all cylinders. There is an increase in focus and confidence.

But once you get used to it, you tend to lose the trick of focusing at will. Pramiracetam is said to be great for long intense study sessions or facing the logical test.

It can help you with presentations before the board or big reputed companies. The nootropic makes it possible for you to handle long, tedious, and difficult tasks, that looked impossible.

Conclusion

We hope you enjoyed our blog about Pramiracetam and its properties. The nootropic is a drug that promises to benefit mental performance, and memory and the effects are relatively safe.

References

1.^Fang Z, Liu X, Xiao Y, Jiang W Pharmacokinetics of pramiracetam in animals Hua Xi Yi Ke Da Xue Xue Bao.(1999 Dec)

2.^Parnetti L Clinical pharmacokinetics of drugs for Alzheimer’s disease Clin Pharmacokinet.(1995 Aug)

3.^Xiao P, Staubli U, Kessler M, Lynch G Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus Hippocampus. (1991 Oct)

4.^Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent.()

5.^Mondadori C, Bhatnagar A, Borkowski J, Häusler A Involvement of a steroidal component in the mechanism of action of piracetam-like nootropics Brain Res.(1990 Jan 1)

6.^Mondadori C, Petschke F Do piracetam-like compounds act centrally via peripheral mechanismsBrain Res. (1987 Dec 1)

7.^Mondadori C, Ducret T, Häusler AElevated corticosteroid levels block the memory-improving effects of nootropics and cholinomimeticsPsychopharmacology (Berl). (1992)

8.^Brust P Reversal of scopolamine-induced alterations of choline transport across the blood-brain barrier by the nootropics piracetam and pramiracetam Arzneimittelforschung.(1989 Oct)

9.^Mauri M, Sinforiani E, Reverberi F, Merlo P, Bono G Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers Arch Gerontol Geriatr.(1994 Mar-Apr)

10.^Claus JJ, Ludwig C, Mohr E, Giuffra M, Blin J, Chase TN Nootropic drugs in Alzheimer’s disease: symptomatic treatment with pramiracetam Neurology. (1991 Apr)

11.^Corasaniti MT, Paoletti AM, Palma E, Granato T, Navarra M, Nisticò G Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the ratFunct Neurol. (1995 May-Jun)

12. Pugsley T.A., Shih Y.H. “Some neurochemical properties of nootropic(CI-879), a new cognition-enhancing agent” Drug Development Research Volume 3, Issue 5, pages 407–420, 1983 (source)

13. Brust P. “Reversal of scopolamine-induced alterations of choline transport across the blood-brain barrier by the nootropics piracetam and nootropic.” Arzneimittelforschung. 1989 Oct;39(10):1220-2. (source)

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